Changes between Version 25 and Version 26 of public


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Timestamp:
Apr 27, 2011, 5:02:05 PM (13 years ago)
Author:
stagge
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    v25 v26  
    2121
    2222Specifically, we investigate how this bacterium senses oxygen, or the associated changes in oxidation/reduction balance, via the Fnr and ArcA proteins, how these systems interact with other regulatory systems, and how the redox response of an ''E. coli'' population is generated from the responses of single cells. There are five sub-projects to determine system properties and behaviour and three sub-projects to employ different and complementary modelling approaches using published data sets and data emerging from our own work. We construct increasingly elaborate models of the system at different levels of detail, which are used to generate new hypotheses and influence further experimental design.
    23 ==== Workpackages ====
    24 || [wiki:public/WP1.1   WP1.1 Molecular Interations & Regulatory Modules (Poole & Green)] || WP1.2 Carbon & Electron Fluxes (Teixeira de Mattos) || WP13 WP1.3 Isogenic Mutants (Bettenbrock) || WP14 WP1.4 Single Cells (Bettenbrock & Gilles)||
    25 || [wiki:public/WP2.1.1   WP2.1.1 Agent-based Modelling (Holcombe & Maleki-Dizaji)] || [wiki:public/WP2.1.2 WP2.1.2 From ''Escherichia coli'' Workflow using Taverna and Web Services (Holcombe & Maleki-Dizaji & Rolfe)]|| [wiki:publicWP21 WP2.1.3 Detailed Kinetic Model to predict internal pyruvate concentrations in E. coli during transition to micro-aerobic growth (Holcombe & Maleki-Dizaji & Green & Rolfe)] ||WP2.2 Reduced-order modelling (Gilles) ||  [wiki:public/WP23 WP2.3 Detailed Kinetic Modelling (Sauter & Sawodny)] ||
    26 ==== Personal Pages ====
    27 || [http://www.shef.ac.uk/mbb Sheffield MBB]          || [wiki:public/RPoole   Robert Poole] || [wiki:public/JGreen   Jeff Green] || [wiki:public/AGraham   Alison Graham] || [wiki:public/MRolfe   Matthew Rolfe] || ||
     23
     24==== People of SUMO,,2,, ====
     25|| [http://www.shef.ac.uk/mbb Sheffield MBB]          || Robert Poole (project leader) || Jeff Green || Wenjing Jia || Matthew Rolfe || Tacita Nye ||
    2826|| [http://www.shef.ac.uk/dcs Sheffield DCS]          || Mike Holcombe || Afsaneh Maleki-Dizaji || || || ||
    29 || [http://www.science.uva.nl/sils Amsterdam SILS]    || Joost Teixeira de Mattos || Alex Ter Beek || || || ||
    30 || [http://www.isys.uni-stuttgart.de/ Stuttgart ISYS] || [wiki:public/OliverSawodny Oliver Sawodny] || [wiki:public/SebastianHenkel Sebastian Henkel] || [wiki:public/ThomasSauter Thomas Sauter] (now: Université du Luxembourg)|| || ||
    31 || [http://www.mpi-magdeburg.mpg.de/ Magdeburg MPI]   || Ernst Dieter Gilles || Katja Bettenbrock || [wiki:public/MichaelEderer Michael Ederer] || Sonja Steinsiek || Stefan Stagge||
     27|| [http://www.science.uva.nl/sils Amsterdam SILS]    || Joost Teixeira de Mattos || Maikel Verouden || Angie Vreugdenhil || || ||
     28|| [http://www.isys.uni-stuttgart.de/ Stuttgart ISYS] || Oliver Sawodny || Michael Ederer || Sebastian Henkel || || ||
     29|| [http://www.mpi-magdeburg.mpg.de/ Magdeburg MPI]   || Katja Bettenbrock || Sonja Steinsiek || Stefan Stagge|| || ||
    3230
    3331==== Publications ====
    34 (related to SUMO, which acknowledge the support by SysMO)
     32(related to SUMO and SUMO,,2,,, which acknowledge the support by SysMO)
    3533 * Bekker M., de Vries, S., Ter Beek, A., Hellingwerf, K. and Teixeira de Mattos, M. (2009). Non-electrogenic respiration by Escherichia coli: the quinol oxidase cytochrome bd-II does not contribute to oxidative phosphorylation, submitted.
    3634 * Green, J., Crack, J.C., Thomson, A.J. and Le Brun, N.E. (2009) Bacterial sensors of oxygen. Current Opinions in Microbiology 12, 145-151.
    … …  
    3836 * Maleki-Dizaji, S., Holcombe, M., Rolfe, M.D., Fisher, P., Green, J., Poole, R.K., Graham, A.I. and SysMO-SUMO consortium. (2009) A systematic approach to understanding Escherichia coli responses to oxygen: from microarray raw data to pathways and published abstracts. Online Journal of Bioinformatics 10, 51-59.
    3937 * Shepherd, M., Sanguinetti, G., Cook, G.M. and Poole, R.K. (2009) The AppBC quinol oxidase (cytochrome bd-II) of Escherichia coli: up-regulation in a cytochrome bd-I mutant in concert with acid resistance genes, submitted.
     38 * Steinsiek S, Frixel S, Stagge S; SUMO, Bettenbrock K. (2011) Characterization of E. coli MG1655 and frdA and sdhC mutants at various aerobiosis levels, J Biotechnol. [Epub ahead of print]
    4039
    4140=== Contact ===