Changes between Version 7 and Version 8 of public

Timestamp:

Apr 28, 2009, 1:39:44 PM (15 years ago)

Author:

henkel

Comment:

--

public

@@ -16 +16 @@
    5. The system is biologically, medically and industrially significant.
 
-This systems approach will reveal new insight into the adaptations that occur in response to changes in oxygen availability and offer opportunities for efficient re-engineering for industrial purposes and target-identification for medical applications. We will collectively obtain and analyse, using commonly agreed protocols, highly reproducible transcriptomic, proteomic, metabolomic and biochemical data sets that describe the dynamics of the response to oxygen. Data sets will be integrated to elaborate predictive mathematical and computer science models in an iterative process of model-based hypothesis generation and experimental design.
+This systems approach reveals new insight into the adaptations that occur in response to changes in oxygen availability and offer opportunities for efficient re-engineering for industrial purposes and target-identification for medical applications. We collectively obtain and analyse, using commonly agreed protocols, highly reproducible transcriptomic, proteomic, metabolomic and biochemical data sets that describe the dynamics of the response to oxygen. Data sets are integrated to elaborate predictive mathematical and computer science models in an iterative process of model-based hypothesis generation and experimental design.
 
-Specifically, we will investigate how this bacterium senses oxygen, or the associated changes in oxidation/reduction balance, via the Fnr and ArcA proteins, how these systems interact with other regulatory systems, and how the redox response of an ''E. coli'' population is generated from the responses of single cells. There are five sub-projects to determine system properties and behaviour and three sub-projects to employ different and complementary modelling approaches using published data sets and data emerging from our own work. We will construct increasingly elaborate models of the system at different levels of detail, which will be used to generate new hypotheses and influence further experimental design.
+Specifically, we investigate how this bacterium senses oxygen, or the associated changes in oxidation/reduction balance, via the Fnr and ArcA proteins, how these systems interact with other regulatory systems, and how the redox response of an ''E. coli'' population is generated from the responses of single cells. There are five sub-projects to determine system properties and behaviour and three sub-projects to employ different and complementary modelling approaches using published data sets and data emerging from our own work. We construct increasingly elaborate models of the system at different levels of detail, which are used to generate new hypotheses and influence further experimental design.
 ==== Workpackages ====
 || WP1.1 Molecular Interations & Regulatory Modules (Poole & Green) || WP1.2 Carbon & Electron Fluxes (Teixeira de Mattos) || WP13 WP1.3 Isogenic Mutants (Bettenbrock) || WP14 WP1.4 Single Cells (Bettenbrock & Gilles)||
@@ -26 +26 @@
 || [http://www.shef.ac.uk/dcs Sheffield DCS]          || Mike Holcombe || Afsaneh Maleki-Dizaji || || || ||
 || [http://www.science.uva.nl/sils Amsterdam SILS]    || Joost Teixeira de Mattos || Alex Ter Beek || || || ||
-|| [http://www.isys.uni-stuttgart.de/ Stuttgart ISYS] || Oliver Sawodny || Sebastian Henkel || Thomas Sauter (now [http://wwwen.uni.lu/forschung/fstc/life_sciences_research_unit Université du Luxembourg]) || || ||
+|| [http://www.isys.uni-stuttgart.de/ Stuttgart ISYS] || Oliver Sawodny || Sebastian Henkel || Thomas Sauter || || ||
 || [http://www.mpi-magdeburg.mpg.de/ Magdeburg MPI]   || Ernst Dieter Gilles || Katja Bettenbrock || Michael Ederer || Sonja Steinsiek || Stefan Stagge||
 
@@ -35 +35 @@
 
 === Upcoming Events ===
-|| 2009 May 19th/20th       || SysMO status seminar (including evaluation) in Vienna ||
+|| 2009 May 19th/20th || SysMO status seminar (including evaluation) in Vienna ||
 || 2009 Autumn || SUMO meeting ||